BOS Basel 2026 — a must-attend event in pharmaceutical outsourcing that Holodiag never misses! ❓Need to determine the molecular structure of an unknown impurity? ❓Need to confirm the solid form of your compound? ❓Facing crystallization, [...]

Last week, Emre Yörük, Ph.D. was at the 2026 conference of the French Crystallography Association (AFC-cristal) in Villeneuve d’Ascq to present applications of electron diffraction in the pharmaceutical industry. His talk was focused on crystal [...]

🤝 Highlighting a 20-year collaboration between Malvern Panalytical and Holodiag – Now part of Icrom Since the early days of Holodiag, adopting cutting-edge technologies has been a key priority for Dr.Pierric Marchand. One of his [...]

🔬 #Holodiag at #Chemspec — A productive edition! Again this year, rich discussions covering topics such as: ▪ Crystallization process optimization (yield/purity, particle engineering) ▪ Enantiomer separation ▪ Product recovery ▪ Molecular structure determination of [...]

Another #DCATWeek in New York came to an end 🗽 A big thank you to everyone who took the time to meet with #Holodiag & #Icrom and discuss your projects when it comes to solid-state [...]

Impurity detection is often straightforward. Impurity structure determination is not. When conventional techniques (NMR, MS, XRPD) reach their limits, especially with trace-level crystalline impurities or extremely small crystals, electron diffraction can provide the missing piece. [...]

🥳 Holodiag is excited to welcome Emre Yörük, Ph.D., who joined us a few days ago as Electron Diffraction Expert. Emre earned his doctorate from Grenoble Alpes University in 2022, specializing in low-dose electron diffraction [...]

BOS Manchester is a wrap! After more than a decade away from the UK, Holodiag – Now part of Icrom made its return, this time side-by-side with Icrom Srl. Dr.Pierric Marchand captivated the audience with [...]

Infrared spectroscopy is one of the most versatile and reliable tools for characterizations in pharmaceutical development. At Holodiag, we use IR analysis to: ✔️ Identify and confirm molecular structures ✔️ Distinguish between solid states ✔️ [...]

Three intense days in Frankfurt promoting electron diffraction’s astonishing applications. Holodiag and Icrom were attending the 2025’s edition together to discuss niche APIs and solid state expertise 🤝 👉 Get your molecular structure from a [...]

Dr. Pierric MARCHAND – Founder & General Manager of Holodiag – and Pierfrancesco MOROSINI – President & CEO of Icrom, President of AschimFarma, and President of Holodiag – gave an interview highlighting the group’s strengths [...]

🎯 Holodiag attended FARMAFORUM for the second time to highlight its services dedicated to solid state. This year, we’ve been focusing on a new equipment, unique in Europe: the electron diffractometer. This powerful device allows [...]

🚀 👨‍🔬 IT’S HERE! 🔥 🎉 We are excited to announce that Holodiag’s ED-1 electron diffractometer is now in the lab, with qualification in progress. 𝐇𝐨𝐥𝐨𝐝𝐢𝐚𝐠 𝐢𝐬 𝐩𝐫𝐨𝐮𝐝 𝐭𝐨 𝐛𝐞 𝐭𝐡𝐞 𝐨𝐧𝐥𝐲 𝐥𝐚𝐛𝐨𝐫𝐚𝐭𝐨𝐫𝐲 𝐢𝐧 𝐄𝐮𝐫𝐨𝐩𝐞 [...]

Holodiag and Icrom were at Interphex Japan at Tokyo Big Sight! 🎌 INTERPHEX WEEK is Japan’s largest B-to-B trade show for pharmaceutical, biotechnology, and regenerative medicine technologies. The Icrom team from Italy, specialized in high-tech [...]

Another amazing week at BOS Basel 2025 for Holodiag – Now part of Icrom! This time with Icrom Srl. Biotech Outsourcing Strategies Events bring together stakeholders in R&D outsourcing to share experience, build existing outsourcing [...]

Chemspec Europe is a key event for the fine and speciality chemicals industry. With a highly specialised profile, the exhibition is the place to be for purchasers and agents to meet with manufacturers, suppliers and [...]

🔴 Besides from asymmetric synthesis, enantiomer separation is a very effective option, especially by crystallization. Holodiag’s acute expertise in this field opens various options, starting from racemic or excess mixtures, with or without resolving agents. [...]

Electron diffraction is the most recent addition to the crystallographic toolkit and allows researchers to determine crystal structures directly from nanocrystals of sizes around 10-1000 nm. The ELDICO ED-1 – is designed by crystallographers for [...]

And that’s a wrap — #DCAT Week 2025 has come to an end! A successful first participation for #Holodiag alongside the great #Icrom team. We’re grateful for the insightful meetings and valuable connections made. Definitely [...]

❕ Few weeks ago, we announced the acquisition of the ELDICO ED-1 electron diffractometer, state-of-the-art equipment. What applications for pharmaceutical development ? The growth of single crystals has limits: it guarantees neither success nor control [...]

👨‍🔬 Thrilled to welcome Clement Pinetre to Holodiag as our new crystallization researcher! His expertise in polymorphism, crystallization and solid state will be a key asset in pushing the boundaries of solid-state innovation. Recently graduated [...]

‼️ UPCOMING BIG NEW TOY FOR THE LAB ‼️ Holodiag is proud to announce the acquisition of an electron diffractometer: the ELDICO ED-1. Becoming the first company in Europe having such an equipment, we warmly [...]

Holodiag is proud to join DCAT (Drug, Chemical & Associated Technologies Association), the premier association for the global bio-pharmaceutical manufacturing value chain. A new step for our company which continues to progress 👌  

▶ Laser PSD is an important analytical measurement as particle size is an essential data in the development of drug products (dissolution rate, bioavailability). Granulometry method development and validation is challenging. Indeed, this measurement is [...]

☑ Holodiag is now FDA registered for its analytical services (XRPD, DVS, DSC, Laser PSD, TGA, …). Congratulations to the team for this achievement! #FDA #pharma #analyses #QC

After weeks of preparation, CPHI 2024 is already over! 2,400+ exhibitors 60,000+ visitors ➡ Definitely the place to be for Holodiag! Warm thanks to the welcoming Icrom Srl team, Tuesday night was so nice 🙏 [...]

💊 First edition at Farma Forum Madrid for Holodiag. Thanks to the people who have stopped by our stand! We will surely return! #pharma #polymorphism #smallmolecules    

❗ BREAKING NEWS ❗ 🤝 We are glad to announce that Holodiag has just joined Icrom Srl Group, an Italian API CDMO specialized in development and GMP manufacturing of potent and non-potent Active Ingredients with [...]

  🤝 Great edition of BOS Basel 2024 supported by sunny days ! ☀ This year, Pierric MARCHAND,PhD presented “Where are the reference samples?” », a topic increasingly addressed in pharma. His intervention can be [...]

The density of a powder is important data in pharmaceutical development. 💡 It provides information on its flowability and its capacity to make a tablet. Holodiag offers bulk and tapped density measurement services compliant with [...]

Particles in liquid formulation is a concern, critical for injectable but also parenteral and per os. Also called unexpected, undissolved or undesired particles, they can be of different nature: – Exogenous as dust, metal particles, [...]

It is used for: ◾ formulation control, ◾ crystallinity or amorphous content measurements, ◾ desolvation or polymorphic transition monitoring, ◾ raw material control. Different setups allow to provide specific answers for a given problem on [...]

That is why a complete knowledge of cristalline forms is very important for pharma development. ❕ The more we know about polymorphic forms, the better. If having fully characterized the targeted crystal form is necessary, [...]

📈 Intrinsic dissolution allows to measure the speed of dissolution of a drug substance (pure API). As integral part of API solid form characterization, it is key data for relevant form selection, bioavailability calculations and [...]

❗ ❗Melting temperature is not a property of the molecule❗ ❗ New excerpt from the live QP Pharma with Pierric Marchand #physics #chemistry #molecules  

🎉News in our communication! 🤝 We are delighted to announce our partnership with QP Pharma (support in pharmaceutical quality and industrial performance)! 👉The goal? Demystify crystallization processes, polymorphism and the solid state in a relaxed [...]

  Dr.Pierric MARCHAND and Léa TEZE-COPREAUX were exhibiting at BioFit Marseille this week to represent Holodiag. Meeting with biotechs having early-stage projets is essential to be identified for future collaboration. See you next year ! [...]

Access to reference samples of such crystalline impurities is a critical step for a proper XRPD analytical development and validation methods. Holodiag supports you with polymorphic form identification (screening), reference samples preparation, XRPD method development [...]

❕ BREAKING NEWS ❕ 🤝 Holodiag is delighted to announce the arrival of a new collaborator, Robin MONZAT 👨‍⚕️ As Quality Director, Robin will strengthen Holodiag’s quality assurance and lead us towards GMP certification. #GMP [...]

  This year again, we were delighted to be at CPhI ! This time in the beautiful city of Barcelona.  

How to solve polymorphic form, identification, purity profil, LOD in drug substance and drug product ? Our services are applicable on pure API, tablets, suspensions, ointments, … Ask Holodiag for XRPD method development and validation.

A second Dynamic Vapor Sorption (DVS) device has joigned the lab ! Our systems allow to monitor sample mass variation vs. Relative Humidity (RH).

Research Tax Credit (RTC or CIR in french) certification has been renewed for 2023, 2024, 2025, 2026 and 2027 !

Holodiag was at BOS 2023 in Basel This year again we had the pleasure to exhibit at BOS congress in Basel. Biotech Outsourcing Strategies scope is primarily development stage CMC outsourcing for small molecules, biologics [...]

Aurélien LEMERCIER, PhD strengthens the team of researchers dedicated to crystallization processes and Anthony MARTINS the team of research assistants. Contributing to respond more quickly to the needs of our customers.   A.LEMERCIER, PhD A.MARTINS

A second X-Ray Powder Diffratometer from Malvern Panalytical has joined Holodiag’s lab ! Meet the twins right bellow !

Chemspec Europe is a key event for the fine and speciality chemicals industry. Like the last years, Holodiag is attending the event as a visitor. See you there on the 24th and 25th of May [...]

Cocrystal is an interesting crystalline structure for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification : the so-called screening. Then further studies are necessary for an accurate description of the specific features [...]

According to ICH Q6A, polymorphism is described as: « The occurence of different crystalline forms of the same drug substance. This may include solvation or hydration products (also know as pseudopolymorphs) and amorphous forms. » [...]

Holodiag’s analytical methods are apllicable to toxic samples down to 50 ng/m3. Thanks to laminar flow hood systems, HPAPIs, cytotoxic compounds and CMR substances can be handled with high security by our scientific team. Example [...]

Indeed, these analyses allow to get information about: • melting • (re)crystallization • stable/metastable phases • monotropy/nantiotropy • amorphous/Tg • hydrates/solvates • decomposition/degradation • temperature • enthalpy • stability • compatibility and more ! Holodiag [...]

Drug products produced by lyophilization are typically amorphous and show higher dissolution rate and sulubility. However, undesired crystallization may occur, resulting in a lower dissolution rate or even undesirable particles. Holodiag performs specific investigations to [...]

Holodiag will attend as a visitor the new edition of BioFit based in Strasbourg this year ! See you there in three weeks !

Are you facing issues or are you looking for scientific discussions related to solid state characterization, polymorphism, crystallization processes ? Holodiag attends CPhI in Frankfurt as a visitor, can’t wait to meet you there !

InfraRed is a well-known technique for molecular structure identification. It is also used to identify polymorphism in solid samples. Holodiag performs these analyses on high potent product down to 50 ng/m3.

Particle size and shape are crucial parameters in the pharmaceutical industry because it influences many material properties. Consequences are numerous especially for filtration and drying steps. Holodiag provides advanced analytical services for PSD with a [...]

Various formulations can be analyzed by XRPD to identify the crystal form of an API. Among classical ones, there are: • spray • suppository • capsule • transdermal patche • suspension • ointment • tablet [...]

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Holodiag will be at BOS Basel 2022 as an exhibitor next week ! The event will cover discovery, small molecule CMC and biologics CMC outsourcing. You have interest in: • solid state characterization ? (XRPD, [...]

Holodiag will be present at Chemspec Europe – Int. Exhibition for Fine & Speciality Chemicals, as a visitor, on next 31rst of May & 1rst of June in Frankfurt ! Dedicated to solid state and [...]