Holodiag develops scalable crystallization processes for industrial production of fine chemicals.
Our scientific team performs the development of crystallization conditions according to the molecule’s polymorphism, solubility, supersaturation, nucleation and growth.
We develop processes at lab scale up to kilolab, aiming at scalability and processability. Development with respects to specific features of industrial scale (cooling rate, solvent cost, …)
We have in depth-expertise on crystallization processes: development from scratch, optimization of existing processes and troubleshooting with minimum variations.
We offer our customers real-time monitoring of studies through scheduled reporting and steering committees. All delivered reports provide detailed information and advice to make the right choices for all further development steps.
We work to generate and gather all the necessary knowledge for crystallization process development : polymorphism, solubility, stability, nucleation, growth, supersaturation, phase diagram…
Holodiag, expert CRO dedicated to pharma solid state and crystallization of small molecules