‼️ UPCOMING BIG NEW TOY FOR THE LAB ‼️ Holodiag is proud to announce the acquisition of an electron diffractometer: the ELDICO ED-1. Becoming the first company in Europe having such an equipment, we warmly [...]

Holodiag is proud to join DCAT (Drug, Chemical & Associated Technologies Association), the premier association for the global bio-pharmaceutical manufacturing value chain. A new step for our company which continues to progress 👌  

▶ Laser PSD is an important analytical measurement as particle size is an essential data in the development of drug products (dissolution rate, bioavailability). Granulometry method development and validation is challenging. Indeed, this measurement is [...]

☑ Holodiag is now FDA registered for its analytical services (XRPD, DVS, DSC, Laser PSD, TGA, …). Congratulations to the team for this achievement! #FDA #pharma #analyses #QC

After weeks of preparation, CPHI 2024 is already over! 2,400+ exhibitors 60,000+ visitors ➡ Definitely the place to be for Holodiag! Warm thanks to the welcoming Icrom Srl team, Tuesday night was so nice 🙏 [...]

💊 First edition at Farma Forum Madrid for Holodiag. Thanks to the people who have stopped by our stand! We will surely return! #pharma #polymorphism #smallmolecules    

❗ BREAKING NEWS ❗ 🤝 We are glad to announce that Holodiag has just joined Icrom Srl Group, an Italian API CDMO specialized in development and GMP manufacturing of potent and non-potent Active Ingredients with [...]

  🤝 Great edition of BOS Basel 2024 supported by sunny days ! ☀ This year, Pierric MARCHAND,PhD presented “Where are the reference samples?” », a topic increasingly addressed in pharma. His intervention can be [...]

The density of a powder is important data in pharmaceutical development. 💡 It provides information on its flowability and its capacity to make a tablet. Holodiag offers bulk and tapped density measurement services compliant with [...]

It is used for: ◾ formulation control, ◾ crystallinity or amorphous content measurements, ◾ desolvation or polymorphic transition monitoring, ◾ raw material control. Different setups allow to provide specific answers for a given problem on [...]

That is why a complete knowledge of cristalline forms is very important for pharma development. ❕ The more we know about polymorphic forms, the better. If having fully characterized the targeted crystal form is necessary, [...]

📈 Intrinsic dissolution allows to measure the speed of dissolution of a drug substance (pure API). As integral part of API solid form characterization, it is key data for relevant form selection, bioavailability calculations and [...]

❗ ❗Melting temperature is not a property of the molecule❗ ❗ New excerpt from the live QP Pharma with Pierric Marchand #physics #chemistry #molecules  

🎉News in our communication! 🤝 We are delighted to announce our partnership with QP Pharma (support in pharmaceutical quality and industrial performance)! 👉The goal? Demystify crystallization processes, polymorphism and the solid state in a relaxed [...]

  Dr.Pierric MARCHAND and Léa TEZE-COPREAUX were exhibiting at BioFit Marseille this week to represent Holodiag. Meeting with biotechs having early-stage projets is essential to be identified for future collaboration. See you next year ! [...]

Access to reference samples of such crystalline impurities is a critical step for a proper XRPD analytical development and validation methods. Holodiag supports you with polymorphic form identification (screening), reference samples preparation, XRPD method development [...]

❕ BREAKING NEWS ❕ 🤝 Holodiag is delighted to announce the arrival of a new collaborator, Robin MONZAT 👨‍⚕️ As Quality Director, Robin will strengthen Holodiag’s quality assurance and lead us towards GMP certification. #GMP [...]

  This year again, we were delighted to be at CPhI ! This time in the beautiful city of Barcelona.  

How to solve polymorphic form, identification, purity profil, LOD in drug substance and drug product ? Our services are applicable on pure API, tablets, suspensions, ointments, … Ask Holodiag for XRPD method development and validation.

A second Dynamic Vapor Sorption (DVS) device has joigned the lab ! Our systems allow to monitor sample mass variation vs. Relative Humidity (RH).

Research Tax Credit (RTC or CIR in french) certification has been renewed for 2023, 2024, 2025, 2026 and 2027 !

Holodiag was at BOS 2023 in Basel This year again we had the pleasure to exhibit at BOS congress in Basel. Biotech Outsourcing Strategies scope is primarily development stage CMC outsourcing for small molecules, biologics [...]

Aurélien LEMERCIER, PhD strengthens the team of researchers dedicated to crystallization processes and Anthony MARTINS the team of research assistants. Contributing to respond more quickly to the needs of our customers.   A.LEMERCIER, PhD A.MARTINS

A second X-Ray Powder Diffratometer from Malvern Panalytical has joined Holodiag’s lab ! Meet the twins right bellow !

Chemspec Europe is a key event for the fine and speciality chemicals industry. Like the last years, Holodiag is attending the event as a visitor. See you there on the 24th and 25th of May [...]

Cocrystal is an interesting crystalline structure for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification : the so-called screening. Then further studies are necessary for an accurate description of the specific features [...]

According to ICH Q6A, polymorphism is described as: « The occurence of different crystalline forms of the same drug substance. This may include solvation or hydration products (also know as pseudopolymorphs) and amorphous forms. » [...]

Holodiag’s analytical methods are apllicable to toxic samples down to 50 ng/m3. Thanks to laminar flow hood systems, HPAPIs, cytotoxic compounds and CMR substances can be handled with high security by our scientific team. Example [...]

Indeed, these analyses allow to get information about: • melting • (re)crystallization • stable/metastable phases • monotropy/nantiotropy • amorphous/Tg • hydrates/solvates • decomposition/degradation • temperature • enthalpy • stability • compatibility and more ! Holodiag [...]

Drug products produced by lyophilization are typically amorphous and show higher dissolution rate and sulubility. However, undesired crystallization may occur, resulting in a lower dissolution rate or even undesirable particles. Holodiag performs specific investigations to [...]

Holodiag will attend as a visitor the new edition of BioFit based in Strasbourg this year ! See you there in three weeks !

Are you facing issues or are you looking for scientific discussions related to solid state characterization, polymorphism, crystallization processes ? Holodiag attends CPhI in Frankfurt as a visitor, can’t wait to meet you there !

InfraRed is a well-known technique for molecular structure identification. It is also used to identify polymorphism in solid samples. Holodiag performs these analyses on high potent product down to 50 ng/m3.

Particle size and shape are crucial parameters in the pharmaceutical industry because it influences many material properties. Consequences are numerous especially for filtration and drying steps. Holodiag provides advanced analytical services for PSD with a [...]

Various formulations can be analyzed by XRPD to identify the crystal form of an API. Among classical ones, there are: • spray • suppository • capsule • transdermal patche • suspension • ointment • tablet [...]

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Holodiag will be at BOS Basel 2022 as an exhibitor next week ! The event will cover discovery, small molecule CMC and biologics CMC outsourcing. You have interest in: • solid state characterization ? (XRPD, [...]

Holodiag will be present at Chemspec Europe – Int. Exhibition for Fine & Speciality Chemicals, as a visitor, on next 31rst of May & 1rst of June in Frankfurt ! Dedicated to solid state and [...]