![](https://www.holodiag.com/wp-content/uploads/2022/09/XRPD-2-scaled.jpg)
X-Ray Powder Diffraction (XRPD)
Our two Malvern Panalytical Empyrean S3 are equipped with a PIXcel detector.
Their different setups allow to provide specific answers for a given problem on a wide range of samples:
• Low concentrations of API
• Wet powder
• Slurries or suspensions
• Tabs or pills
• Very low quantities, etc.
![](https://www.holodiag.com/wp-content/uploads/2022/09/DSC-1-no_label-scaled.jpg)
Differential Scanning Calorimetry (DSC)
Our DSC, a Mettler Toledo DSC 3+ allows to work on a broad range of temperatures (- 70 °C up to more than 300 °C).
Heating and cooling rates (from 0.01 °C/min up to 100 °C/min) allow to find the best compromise between resolution and intensity of the thermal events, depending on the aim of the analysis.
![](https://www.holodiag.com/wp-content/uploads/2022/09/DSC-TGA-scaled.jpg)
Thermo-Gravimetric Analysis (TGA)
Our thermal analyzer, a Mettler Toledo TGA/DSC 3+ enables working on a broad range of sub-ambient temperatures (up to 1000 °C).
Heating rates (0.1 to 50 °C/min) give flexibility and better adjustment to experimental needs. Moreover, the high sensitivity of the micro-balance (0.1 µg) and its precision enable sharp detection of the most subtle phenomena.
![](https://www.holodiag.com/wp-content/uploads/2022/10/DVS-2-scaled.jpg)
Dynamic Vapor Sorption (DVS)
Holodiag owns two Dynamic Vapor Sorption (DVS) devices.
Our systems (Surface Measurement System DVS Intrinsic), allow to monitor sample mass variation vs. Relative Humidity (RH).
![](https://www.holodiag.com/wp-content/uploads/2022/09/Infra-Rouge-2-scaled.webp)
Infrared FTIR-ATR (IR)
Holodiag owns a ThermoFisher Nicolet iS5 spectrometer to quickly and accurately perform infrared spectra.
The Attenuated Total Reflection (ATR) system with diamond window allows to easily analyze powders and liquids.
![](https://www.holodiag.com/wp-content/uploads/2022/09/Ultra-Violet-scaled.webp)
Ultra-Violet Spectroscopy (UV)
We own an Agilent Cary 60 Ultra-Violet spectrometer which can perform UV-visible spectra and accurately measure absorbance values.
![](https://www.holodiag.com/wp-content/uploads/2022/09/50-scaled.webp)
Particle Size Diffraction (PSD)
We own a Malvern Mastersizer 3000 granulometer with both modes : dry and liquid.
Our device is fully installed inside a laminar flow hood allowing analyses on toxic samples.
![](https://www.holodiag.com/wp-content/uploads/2022/09/IDR-1R-scaled.webp)
Intrinsic Dissolution Rate (IDR)
Holodiag is equipped with Dissolutest Vision G2 Elite 8 and intrinsic dissolution rate apparatus as described in Pharmacopoeia.
Solution concentration is monitored by HPLC or UV spectroscopy.