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X-Ray Powder Diffaction (XRPD)

Our Malvern Panalytical Empyrean S3 is equipped with a PIXcel detector.

Its different setups allow to provide specific answers for a given problem on a wide range of samples:
• Low concentrations of API
• Wet powder
• Slurry or suspensions
• Tabs or pills
• Very low quantities, etc.

Differential Scanning Calorimetry (DSC)

Our DSC, a Mettler DSC3+ allows to work on a broad range of temperatures (- 70°C up to more than 300 °C).

Heating and cooling rates (from 0.01 °C/min up to 100 °C/min) allow to find the best compromise between resolution and intensity of the thermal events, depending on the aim of the analysis.

Thermo-Gravimetric Analysis (TGA)

Our thermal analyzer, a Perkin Elmer Pyris 1 TGA enables working on a broad range of sub-ambient temperatures (up to 1000 °C).

Heating rates (0.1 to 50 °C/min) give flexibility and better adjustment to experimental needs. Moreover, the high sensitivity of the micro-balance (0.1 µg) and its precision enable sharp detection of the most subtle phenomena.

Dynamic Vapor Sorption (DVS)

Holodiag owns a Dynamic Vapor Sorption (DVS) device.

Our system, a Surface Measurement System DVS Intrinsic, allows to monitor sample mass variation vs. Relative Humidity (RH).

Infrared FTIR-ATR (IR)

Holodiag owns a ThermoFisher Nicolet iS5 spectrometer to quickly and accurately perform infrared spectra.

The Attenuated Total Reflection (ATR) system with diamond window allows to easily analyze powders and liquids.

Ultra-Violet Spectroscopy (UV)

We own a Perkin Elmer Lambda 25 Ultra-Violet spectrometer which can perform UV-visible spectra and accurately measure absorbance values.

Particle Size Diffraction (PSD)

We own a Malvern Mastersizer 3000 granulometer with both modes : dry and liquid.

Our device is fully installed inside a laminar flow hood allowing analysis on toxic samples.

Intrinsic Dissolution Rate (IRD)

Holodiag is equipped with Dissolutest Vision G2 Elite 8 and intrinsic dissolution rate apparatus as described in Pharmacopoeia.

Solution concentration is monitored by HPLC or UV spectroscopy.