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X-Ray Powder Diffraction (XRPD)

Our two Malvern Panalytical Empyrean S3 are equipped with a PIXcel detector.

Their different setups allow to provide specific answers for a given problem on a wide range of samples:
• Low concentrations of API
• Wet powder
• Slurries or suspensions
• Tabs or pills
• Very low quantities, etc.

Differential Scanning Calorimetry (DSC)

Our DSC, a Mettler Toledo DSC 3+ allows to work on a broad range of temperatures (- 70 °C up to more than 300 °C).

Heating and cooling rates (from 0.01 °C/min up to 100 °C/min) allow to find the best compromise between resolution and intensity of the thermal events, depending on the aim of the analysis.

Thermo-Gravimetric Analysis (TGA)

Our thermal analyzer, a Mettler Toledo TGA/DSC 3+ enables working on a broad range of sub-ambient temperatures (up to 1000 °C).

Heating rates (0.1 to 50 °C/min) give flexibility and better adjustment to experimental needs. Moreover, the high sensitivity of the micro-balance (0.1 µg) and its precision enable sharp detection of the most subtle phenomena.

Dynamic Vapor Sorption (DVS)

Holodiag owns two Dynamic Vapor Sorption (DVS) devices.

Our systems (Surface Measurement System DVS Intrinsic), allow to monitor sample mass variation vs. Relative Humidity (RH).

Infrared FTIR-ATR (IR)

Holodiag owns a ThermoFisher Nicolet iS5 spectrometer to quickly and accurately perform infrared spectra.

The Attenuated Total Reflection (ATR) system with diamond window allows to easily analyze powders and liquids.

Ultra-Violet Spectroscopy (UV)

We own an Agilent Cary 60 Ultra-Violet spectrometer which can perform UV-visible spectra and accurately measure absorbance values.

Particle Size Diffraction (PSD)

We own a Malvern Mastersizer 3000 granulometer with both modes : dry and liquid.

Our device is fully installed inside a laminar flow hood allowing analyses on toxic samples.

Intrinsic Dissolution Rate (IDR)

Holodiag is equipped with Dissolutest Vision G2 Elite 8 and intrinsic dissolution rate apparatus as described in Pharmacopoeia.

Solution concentration is monitored by HPLC or UV spectroscopy.