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🔴 Besides from asymmetric synthesis, enantiomer separation is a very effective option, especially by crystallization. Holodiag’s acute expertise in this field opens various options, starting from racemic or excess mixtures, with or without resolving agents. [...]
Electron diffraction is the most recent addition to the crystallographic toolkit and allows researchers to determine crystal structures directly from nanocrystals of sizes around 10-1000 nm. The ELDICO ED-1 – is designed by crystallographers for [...]
❕ Few weeks ago, we announced the acquisition of the ELDICO ED-1 electron diffractometer, state-of-the-art equipment. What applications for pharmaceutical development ? The growth of single crystals has limits: it guarantees neither success nor control [...]
👨🔬 Thrilled to welcome Clement Pinetre to Holodiag as our new crystallization researcher! His expertise in polymorphism, crystallization and solid state will be a key asset in pushing the boundaries of solid-state innovation. Recently graduated [...]
‼️ UPCOMING BIG NEW TOY FOR THE LAB ‼️ Holodiag is proud to announce the acquisition of an electron diffractometer: the ELDICO ED-1. Becoming the first company in Europe having such an equipment, we warmly [...]
▶ Laser PSD is an important analytical measurement as particle size is an essential data in the development of drug products (dissolution rate, bioavailability). Granulometry method development and validation is challenging. Indeed, this measurement is [...]
Particles in liquid formulation is a concern, critical for injectable but also parenteral and per os. Also called unexpected, undissolved or undesired particles, they can be of different nature: – Exogenous as dust, metal particles, [...]
It is used for: ◾ formulation control, ◾ crystallinity or amorphous content measurements, ◾ desolvation or polymorphic transition monitoring, ◾ raw material control. Different setups allow to provide specific answers for a given problem on [...]
🎉News in our communication! 🤝 We are delighted to announce our partnership with QP Pharma (support in pharmaceutical quality and industrial performance)! 👉The goal? Demystify crystallization processes, polymorphism and the solid state in a relaxed [...]
Access to reference samples of such crystalline impurities is a critical step for a proper XRPD analytical development and validation methods. Holodiag supports you with polymorphic form identification (screening), reference samples preparation, XRPD method development [...]
Cocrystal is an interesting crystalline structure for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification : the so-called screening. Then further studies are necessary for an accurate description of the specific features [...]
Indeed, these analyses allow to get information about: • melting • (re)crystallization • stable/metastable phases • monotropy/nantiotropy • amorphous/Tg • hydrates/solvates • decomposition/degradation • temperature • enthalpy • stability • compatibility and more ! Holodiag [...]
Drug products produced by lyophilization are typically amorphous and show higher dissolution rate and sulubility. However, undesired crystallization may occur, resulting in a lower dissolution rate or even undesirable particles. Holodiag performs specific investigations to [...]
Particle size and shape are crucial parameters in the pharmaceutical industry because it influences many material properties. Consequences are numerous especially for filtration and drying steps. Holodiag provides advanced analytical services for PSD with a [...]
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Holodiag, expert CRO dedicated to pharma solid state and crystallization of small molecules