When a solid state is highlighted through solid state screenings, our scientists investigate the physico-chemical properties of the new solid form.
Once a screening is completed, each solid form is further investigated. After a small scale-up, we proceed to full solid state and physico-chemical characterization (stability, solubility, dissolution) aiming at form selection.
We can measure pure API dissolution by IDR (Eu. Ph. 2.9.29), providing relevant comparisons of dissolution for various polymorphs/salts/co-crystals.
Relative stability of selected phases (stable/metastable polymorphs, salt hygroscopicity, …) are investigated vs. temperature, relative humidity, solvents and more.
We support our customers to select the most suitable solid form according to the objectives: bioavailability, dissolution, stability, yield, processability, formulation development, IP…
We perform investigations from evaluation to full solubility profile vs. temperature in solvent mixtures or biologic media (e.g. SGF, Fessif, Fassif).
Holodiag, expert CRO dedicated to pharma solid state and crystallization of small molecules