Knowing the structure is not always enough. For a chiral molecule, there is another crucial question: Which absolute configuration do I actually have? R or S? Single-crystal X-ray diffraction can answer this question — but [...]
Everything looked familiar: Known compound. Known polymorphs. Known powder X-ray diffraction patterns. And then… one unexpected peak appears in the XRPD pattern. Where does it come from? A new polymorph? A known form that behaves [...]
Anyone working in chemical development or production knows the problem: an unexpected HPLC peak appears. What is it? And then begins the investigation: isolation, MS, NMR, more isolation, more analyses… sometimes with only tiny amounts [...]
Last week, Emre Yörük, Ph.D. was at the 2026 conference of the French Crystallography Association (AFC-cristal) in Villeneuve d’Ascq to present applications of electron diffraction in the pharmaceutical industry. His talk was focused on crystal [...]
🤝 Highlighting a 20-year collaboration between Malvern Panalytical and Holodiag – Now part of Icrom Since the early days of Holodiag, adopting cutting-edge technologies has been a key priority for Dr.Pierric Marchand. One of his [...]
🔬 #Holodiag at #Chemspec — A productive edition! Again this year, rich discussions covering topics such as: ▪ Crystallization process optimization (yield/purity, particle engineering) ▪ Enantiomer separation ▪ Product recovery ▪ Molecular structure determination of [...]
Impurity detection is often straightforward. Impurity structure determination is not. When conventional techniques (NMR, MS, XRPD) reach their limits, especially with trace-level crystalline impurities or extremely small crystals, electron diffraction can provide the missing piece. [...]
🥳 Holodiag is excited to welcome Emre Yörük, Ph.D., who joined us a few days ago as Electron Diffraction Expert. Emre earned his doctorate from Grenoble Alpes University in 2022, specializing in low-dose electron diffraction [...]
Infrared spectroscopy is one of the most versatile and reliable tools for characterizations in pharmaceutical development. At Holodiag, we use IR analysis to: ✔️ Identify and confirm molecular structures ✔️ Distinguish between solid states ✔️ [...]
🔴 Besides from asymmetric synthesis, enantiomer separation is a very effective option, especially by crystallization. Holodiag’s acute expertise in this field opens various options, starting from racemic or excess mixtures, with or without resolving agents. [...]
Electron diffraction is the most recent addition to the crystallographic toolkit and allows researchers to determine crystal structures directly from nanocrystals of sizes around 10-1000 nm. The ELDICO ED-1 – is designed by crystallographers for [...]
❕ Few weeks ago, we announced the acquisition of the ELDICO ED-1 electron diffractometer, state-of-the-art equipment. What applications for pharmaceutical development ? The growth of single crystals has limits: it guarantees neither success nor control [...]
👨🔬 Thrilled to welcome Clement Pinetre to Holodiag as our new crystallization researcher! His expertise in polymorphism, crystallization and solid state will be a key asset in pushing the boundaries of solid-state innovation. Recently graduated [...]
‼️ UPCOMING BIG NEW TOY FOR THE LAB ‼️ Holodiag is proud to announce the acquisition of an electron diffractometer: the ELDICO ED-1. Becoming the first company in Europe having such an equipment, we warmly [...]
▶ Laser PSD is an important analytical measurement as particle size is an essential data in the development of drug products (dissolution rate, bioavailability). Granulometry method development and validation is challenging. Indeed, this measurement is [...]
Particles in liquid formulation is a concern, critical for injectable but also parenteral and per os. Also called unexpected, undissolved or undesired particles, they can be of different nature: – Exogenous as dust, metal particles, [...]
It is used for: ◾ formulation control, ◾ crystallinity or amorphous content measurements, ◾ desolvation or polymorphic transition monitoring, ◾ raw material control. Different setups allow to provide specific answers for a given problem on [...]
🎉News in our communication! 🤝 We are delighted to announce our partnership with QP Pharma (support in pharmaceutical quality and industrial performance)! 👉The goal? Demystify crystallization processes, polymorphism and the solid state in a relaxed [...]
Access to reference samples of such crystalline impurities is a critical step for a proper XRPD analytical development and validation methods. Holodiag supports you with polymorphic form identification (screening), reference samples preparation, XRPD method development [...]
Cocrystal is an interesting crystalline structure for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification : the so-called screening. Then further studies are necessary for an accurate description of the specific features [...]
Indeed, these analyses allow to get information about: • melting • (re)crystallization • stable/metastable phases • monotropy/nantiotropy • amorphous/Tg • hydrates/solvates • decomposition/degradation • temperature • enthalpy • stability • compatibility and more ! Holodiag [...]
Drug products produced by lyophilization are typically amorphous and show higher dissolution rate and sulubility. However, undesired crystallization may occur, resulting in a lower dissolution rate or even undesirable particles. Holodiag performs specific investigations to [...]
Particle size and shape are crucial parameters in the pharmaceutical industry because it influences many material properties. Consequences are numerous especially for filtration and drying steps. Holodiag provides advanced analytical services for PSD with a [...]
Here we go again! 🙌
Dr. Pierric Marchand & Léa TEZE were at CPhI, discussing the endless challenges related to the solid state of small molecules.
CPhI SolidState SmallMolecules Holodiag
