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! One more DVS device !
ServicesA second Dynamic Vapor Sorption (DVS) device has joigned the lab ! Our systems allow to monitor sample mass variation vs. Relative Humidity (RH). Our lab facilities
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RTC certification renewed till 2027 !
OtherResearch Tax Credit (RTC or CIR in french) certification has been renewed for 2023, 2024, 2025, 2026 and 2027 ! Get to know more about CIR/RTC
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BOS Basel 2023
EventsHolodiag was at BOS 2023 in Basel This year again we had the pleasure to exhibit at BOS congress in Basel. Biotech Outsourcing Strategies scope is primarily development stage CMC outsourcing for small molecules, biologics and novel therapeutic entities. The place to be for Holodiag. Dr.Pierric MARCHAND had the opportunity to perform…
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The team is growing !
OtherAurélien LEMERCIER, PhD strengthens the team of researchers dedicated to crystallization processes and Anthony MARTINS the team of research assistants. Contributing to respond more quickly to the needs of our customers. A.LEMERCIER A.MARTINS
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! Big new toy for the lab !
ServicesA second X-Ray Powder Diffratometer from Malvern Panalytical has joined Holodiag's lab ! Meet the twins right bellow ! Our lab equipments
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Chemspec Basel 2023
EventsChemspec Europe is a key event for the fine and speciality chemicals industry. Like the last years, Holodiag is attending the event as a visitor. See you there on the 24th and 25th of May 2023 ! Visit Chemspec here Credits to: Chemspec Europe - Int. Exhibition for Fine &…
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Cocrystals for pharma development
Specific topicsCocrystal is an interesting crystalline structure for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification : the so-called screening. Then further studies are necessary for an accurate description of the specific features (non-congruent solubility). Click here to know more about cocrystal screening !
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Polymorphism is a essential information !
Specific topicsAccording to ICH Q6A, polymorphism is described as: "The occurence of different crystalline forms of the same drug substance. This may include solvation or hydration products (also know as pseudopolymorphs) and amorphous forms." Polymorphism is essential in pharma development for lead selection, solid form selection, regulatory affairs, IP, crystallization process development, robustness,…
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OEL : 50 ng/m3
ServicesHolodiag's analytical methods are apllicable to toxic samples down to 50 ng/m3. Thanks to laminar flow hood systems, HPAPIs, cytotoxic compounds and CMR substances can be handled with high security by our scientific team. Example of equipments under protection:• our Malvern Mastersizer 3000 for particle size distribution (Laser PSD)• our Dynamic Vapor…
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TGA and DSC are key thermal analyses for solid state characterization
ServicesIndeed, these analyses allow to get information about: • melting • (re)crystallization • stable/metastable phases • monotropy/nantiotropy • amorphous/Tg • hydrates/solvates • decomposition/degradation • temperature • enthalpy • stability • compatibility and more ! Holodiag owns a Mettler DSC 3+ and TGA-DSC 3+. Get to know more about these techniques
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Challenging lyophilisate !
Specific topicsDrug products produced by lyophilization are typically amorphous and show higher dissolution rate and sulubility. However, undesired crystallization may occur, resulting in a lower dissolution rate or even undesirable particles. Holodiag performs specific investigations to identify crystalline particles, their origin in order to solve these situations. Please get in touch with us…
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BioFit Strasbourg 2022
EventsHolodiag will attend as a visitor the new edition of BioFit based in Strasbourg this year ! See you there in three weeks ! BioFit 2022
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CPhI Frankfurt 2022
EventsAre you facing issues or are you looking for scientific discussions related to solid state characterization, polymorphism, crystallization processes ? Holodiag attends CPhI in Frankfurt as a visitor, can't wait to meet you there ! CPhI Frankfurt !
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About InfraRed
ServicesInfraRed is a well-known technique for molecular structure identification. It is also used to identify polymorphism in solid samples. Holodiag performs these analyses on high potent product down to 50 ng/m3. About ThermoFisher Nicolet iS5 spectrometer
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PSD, a crucial parameter !
ServicesParticle size and shape are crucial parameters in the pharmaceutical industry because it influences many material properties. Consequences are numerous especially for filtration and drying steps. Holodiag provides advanced analytical services for PSD with a Mastersizer 3000 with both dry and liquid mode. Such a system is fully set and qualified under…
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A multitude of samples can be analyzed by XRPD
ServicesVarious formulations can be analyzed by XRPD to identify the crystal form of an API. Among classical ones, there are: • spray• suppository• capsule• transdermal patche• suspension• ointment• tablet• powder But also unexpected ones ! As: • flea collar• chew stick• IUD for cow• medicated nail polish Get to know more about XRPD analysis
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Holodiag is now registred as a supplier on Scientist.com !
EventsThe e-commerce marketplace network connects byuers and sellers of scientific research services. Click here to visit Scientist.com
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BOS Basel 2022
EventsHolodiag will be at BOS Basel 2022 as an exhibitor next week ! The event will cover discovery, small molecule CMC and biologics CMC outsourcing. You have interest in: • solid state characterization ? (XRPD, Laser PSD, routine QC analyses, development and validation of analyical methods...)• solid state investigations ? (polymorphs, salts, cocristals…
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Chemspec Frankfurt 2022
EventsHolodiag will be present at Chemspec Europe - Int. Exhibition for Fine & Speciality Chemicals, as a visitor, on next 31rst of May & 1rst of June in Frankfurt ! Dedicated to solid state and crystallization process development for fine chemical industry, Holodiag's services include: ✔ Physical characterization & control of…
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