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Particle size and shape
Specific topicsCrystallization is a fundamental process utilized across various industries, including pharmaceuticals, chemicals, and materials science. It involves the formation of solid crystals from a liquid or gas phase, resulting in the separation or purification of substances.ย The size and shape of the particles involved in crystallization plays a crucial role inโฆ
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Cocrystal for pharma development
Specific topicsCocrystal is an interesting material for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification (the so-called screening), then further studies are necessary for an accurate description of the specific features (non-congruent solubility). ๐ฉโ๐ฌ๐จโ๐ฌย Holodiagย performs such investigations. Get to know more about cocrystal screening on our dedicated page โกhttps://www.holodiag.com/what-we-do-solid-state-screening/
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Polymorphism is essential
Specific topicsAccording to ICH Q6A, polymorphism is described as: "๐๐ฉ๐ ๐๐๐๐ข๐๐๐๐๐๐ ๐๐ ๐๐๐๐๐๐๐๐๐ก ๐๐๐ฆ๐ ๐ก๐๐๐๐๐๐ ๐๐๐๐๐ ๐๐ ๐ก๐ฉ๐ ๐ ๐๐๐ ๐๐๐ข๐ ๐ ๐ข๐๐ ๐ก๐๐๐๐. ๐๐ฉ๐๐ ๐๐๐ฆ ๐๐๐๐๐ข๐๐ ๐ ๐๐๐ฃ๐๐ก๐๐๐ ๐๐ ๐ฉ๐ฆ๐๐๐๐ก๐๐๐ ๐๐๐๐๐ข๐๐ก๐ (๐๐๐ ๐ ๐๐๐๐ค๐ ๐๐ ๐๐ ๐๐ข๐๐๐๐๐๐ฆ๐๐๐๐๐ฉ๐ ) ๐๐๐ ๐๐๐๐๐๐ฉ๐๐ข๐ ๐๐๐๐๐ ." โก Polymorphism is essential in pharma development (lead selection, solid form selection, regulatory affairs, IP, crystallization processโฆ
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OEL : 50 ng/m3
ServicesHolodiag's analytical methods are applicable to toxic samples down to ๐๐ ๐ง๐ /๐ฆ๐. Thanks to ๐ฅ๐๐ฆ๐ข๐ง๐๐ซ ๐๐ฅ๐จ๐ฐ ๐ก๐จ๐จ๐ ๐ฌ๐ฒ๐ฌ๐ญ๐๐ฆ๐ฌ, HPAPIs, cytotoxic compounds, CMR substances can be handled with high security by our scientific team. Example of equipments under protection: our ๐๐๐ฅ๐ฏ๐๐ซ๐ง ๐๐๐ฌ๐ญ๐๐ซ๐ฌ๐ข๐ณ๐๐ซ ๐๐๐๐ ๐๐จ๐ซ ๐ฉ๐๐ซ๐ญ๐ข๐๐ฎ๐ฅ๐ ๐ฌ๐ข๐ณ๐ ๐๐ข๐๐๐ซ๐๐๐ญ๐ข๐จ๐ง (๐๐๐ฌ๐๐ซ ๐๐๐) and ourโฆ
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TGA/DSC are key thermal analyses for solid state characterization
ServicesMelting, (re)crystallization, stable/metastable phases, monotropy/enantiotropy, amorphous/Tg, hydrates/solvates, decomposition/degradation, temperature, enthalpy, stability and compatibility studies...and more ! Holodiagย owns Mettler DSC 3+ and TGA-DSCย 3+ Feel free to reach us for such analysisย !
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Challenging lyophilisate !
Specific topics๐๐ซ๐ฎ๐ ๐ฉ๐ซ๐จ๐๐ฎ๐๐ญ๐ฌ ๐ฉ๐ซ๐จ๐๐ฎ๐๐๐ ๐๐ฒ ๐ฅ๐ฒ๐จ๐ฉ๐ก๐ข๐ฅ๐ข๐ณ๐๐ญ๐ข๐จ๐ง ๐๐ซ๐ ๐ญ๐ฒ๐ฉ๐ข๐๐๐ฅ๐ฅ๐ฒ ๐๐ฆ๐จ๐ซ๐ฉ๐ก๐จ๐ฎ๐ฌ ๐๐ง๐ ๐ฌ๐ก๐จ๐ฐ ๐ก๐ข๐ ๐ก๐๐ซ ๐๐ข๐ฌ๐ฌ๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐ง ๐ซ๐๐ญ๐ ๐๐ง๐ ๐ฌ๐จ๐ฅ๐ฎ๐๐ข๐ฅ๐ข๐ญ๐ฒ. โ However, undesired crystallization may occur, resulting in a lower dissolution rate or even undesirable particles. โก Holodiag is specialized in investigations to identify crystalline particles, their origin in order to solve these situations.
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BioFit Strasbourg 2022
Events๐ค Holodiag, expert CRO dedicated to solid state pharma and crystallization processes of small molecules, will attend the new edition of BioFIT Event. See you there in three weeks !
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About Infrared
ServicesInfrared is a well-known technique for molecular structure identification. It is also used to identify polymorphism in solid samples. Holodiag offers these analyzes on high potent product down to 50 ng/m3.
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PSD, a crucial parameter !
ServicesParticle size is a crucial parameter in the pharmaceutical industry because it influences many material properties. Holodiag provides advanced analitycal service for PSD with Mastersizer 3000 with dry and liquid mode. Such a system is fully set and qualified inside a laminar flow hood which allows analyses of all kindsโฆ
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CPhI Frankfurt 2022
EventsAre you facing issues or looking for scientific discussions related to solid state characterization, polymorphism, crystallization processes ? ๐งช Holodiag is a french CRO fully dedicated to these topics since 2006. ๐ We will be delighted to meet you at #CPHIWorldwide2022 in #MesseFrankfurt !
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A multitude of samples can be analyzed by XRPD
ServicesVarious formulations can be analyzed by XRPD to identify the crystal form of an API. โก๏ธ Among classical ones, there are : spray suppository capsule transdermal patche suspension ointment tablet powder โก๏ธ But also unexpected ones ! As : flea collar chew stick IUD for cow medicated nailโฆ
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We stay open during the summer !
Services๐ You work on small molecules and look for a service provider dedicated to solid state ?Let's take the opportunity of this holiday time period to remind that Holodiag is a french CRO providing to pharma and specialty chemical compagnies :โ Analytical services : characterization of solid states such as polymorphism identification.โฆ
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Holodiag is now registred as a supplier on Scientist.com !
EventsThe e-commerce marketplace network connects buyers and sellers of scientific research services. As a pharma company, you a have a new RFP regarding solid state or crystallization process to be submited ? You can get in touch with us easily !
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BOS Basel 2022
EventsHolodiagย will be at BOS Basel 2022 as exhibitor next week ! The event will cover discovery outsourcing, small molecule CMC outsourcing & biologics CMC outsourcing. You have interest in:โ solid state characterization ? (XRPD, PSD, routine QC analyzes, development & validation of analytical methods...)โ solid state investigations ? (screenings ofโฆ
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Chemspec Frankfurt 2022
EventsHolodiag will be present at Chemspec Europe - Int. Exhibition for Fine & Speciality Chemicals on next 31rst of May & 1rst of June in Frankfurt ! Dedicated to solid state and crystallization process development for fine chemical industry, Holodiag's services include: โ Physical characterization & control of solid stateโ Product recoveryโ Yield /โฆ
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