- Pharma-Parc II - Voie de l’Innovation - 27100 Val-de-Reuil - France
- +33 (0) 232 405 826
- contact@holodiag.com
Once a screening is completed, each solid form is further investigated. After a small scale-up, we proceed to full solid state and physico-chemical characterization (stability, solubility, dissolution) aiming at form selection.
We can measure pure API dissolution by IDR (Eu. Ph. 2.9.29), providing relevant comparisons of dissolution for various polymorphs/salts/co-crystals.
Relative stability of selected phases (stable/metastable polymorphs, salt hygroscopicity, …) are investigated vs. temperature, relative humidity, solvents and more.
We support our customers to select the most suitable solid form according to the objectives: bioavailability, dissolution, stability, yield, processability, formulation development, IP…
We perform investigations from evaluation to full solubility profile vs. temperature in solvent mixtures or biologic media (e.g. SGF, Fessif, Fassif).
