XRPD method development and validation
How to solve polymorphic form, identification, purity profil, LOD in drug substance and drug product ? Our services are applicable on pure API, tablets, suspensions, ointments, … Ask Holodiag for XRPD method development and validation.
! One more DVS device !
A second Dynamic Vapor Sorption (DVS) device has joigned the lab ! Our systems allow to monitor sample mass variation vs. Relative Humidity (RH).
Research Tax Credit certification renewed till 2027 !
Research Tax Credit (RTC or CIR in french) certification has been renewed for 2023, 2024, 2025, 2026 and 2027 !
BOS Basel 2023
Holodiag was at BOS 2023 in Basel This year again we had the pleasure to exhibit at BOS congress in Basel. Biotech Outsourcing Strategies scope is primarily development stage CMC outsourcing for small molecules, biologics and novel therapeutic entities. The place to be for Holodiag. Dr.Pierric MARCHAND had the opportunity to perform a conference entitled « I […]
The team is growing !
Aurélien LEMERCIER, PhD strengthens the team of researchers dedicated to crystallization processes and Anthony MARTINS the team of research assistants. Contributing to respond more quickly to the needs of our customers. A.LEMERCIER, PhD A.MARTINS
! Big new toy for the lab !
A second X-Ray Powder Diffratometer from Malvern Panalytical has joined Holodiag’s lab ! Meet the twins right bellow !
Chemspec Basel 2023
Chemspec Europe is a key event for the fine and speciality chemicals industry. Like the last years, Holodiag is attending the event as a visitor. See you there on the 24th and 25th of May 2023 !
Cocrystals for pharma development
Cocrystal is an interesting crystalline structure for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification : the so-called screening. Then further studies are necessary for an accurate description of the specific features (non-congruent solubility).
Polymorphism is a essential information !
According to ICH Q6A, polymorphism is described as: « The occurence of different crystalline forms of the same drug substance. This may include solvation or hydration products (also know as pseudopolymorphs) and amorphous forms. » Polymorphism is essential in pharma development for lead selection, solid form selection, regulatory affairs, IP, crystallization process development, robustness, and more.
OEL : 50 ng/m3
Holodiag’s analytical methods are apllicable to toxic samples down to 50 ng/m3. Thanks to laminar flow hood systems, HPAPIs, cytotoxic compounds and CMR substances can be handled with high security by our scientific team. Example of equipments under protection: • our Malvern Mastersizer 3000 for particle size distribution (Laser PSD) • our Dynamic Vapor Sorption […]
