Undesired particles in liquid formulation: a nightmare avoidable
Particles in liquid formulation is a concern, critical for injectable but also parenteral and per os. Also called unexpected, undissolved or undesired particles, they can be of different nature: – Exogenous as dust, metal particles, joint particles (e.g. silicone/PTFE) – Also, endogenous to the solution as the API can precipitate/recrystallize. Several types of API recrystallization […]
XRPD : the main technique for characterization of pharmaceutical solids
It is used for: ◾ formulation control, ◾ crystallinity or amorphous content measurements, ◾ desolvation or polymorphic transition monitoring, ◾ raw material control. Different setups allow to provide specific answers for a given problem on a wide range of samples: ◾ Low API concentrations ◾ Wet powder ◾ Slurries or suspensions ◾ Tablets or pills […]
Many traps are possible with solid state !
That is why a complete knowledge of cristalline forms is very important for pharma development. ❕ The more we know about polymorphic forms, the better. If having fully characterized the targeted crystal form is necessary, knowledge on the other undesired solid forms is critical and highly recommended. Why ? Because knowing in which conditions the […]
About Intrinsic Dissolution Rate (IDR)
📈 Intrinsic dissolution allows to measure the speed of dissolution of a drug substance (pure API). As integral part of API solid form characterization, it is key data for relevant form selection, bioavailability calculations and solid state dissolution comparisons between various crystal forms. As an expert in solubility measurements, Holodiag offers intrinsic dissolution rate services compliant with […]
Melting temperature
❗ ❗Melting temperature is not a property of the molecule❗ ❗ New excerpt from the live QP Pharma with Pierric Marchand #physics #chemistry #molecules
Holodiag diversifies its communication!
🎉News in our communication! 🤝 We are delighted to announce our partnership with QP Pharma (support in pharmaceutical quality and industrial performance)! 👉The goal? Demystify crystallization processes, polymorphism and the solid state in a relaxed and original way through dynamic lives made in Normandy 💎 While waiting for the next live (date to come), here […]
BioFit Marseille 2023
Dr.Pierric MARCHAND and Léa TEZE-COPREAUX were exhibiting at BioFit Marseille this week to represent Holodiag. Meeting with biotechs having early-stage projets is essential to be identified for future collaboration. See you next year !
Undesired polymorphic forms can be contemplated as crystalline impurities
Access to reference samples of such crystalline impurities is a critical step for a proper XRPD analytical development and validation methods. Holodiag supports you with polymorphic form identification (screening), reference samples preparation, XRPD method development and validation.
New recruitment: Robin MONZAT as Quality Director
❕ BREAKING NEWS ❕ 🤝 Holodiag is delighted to announce the arrival of a new collaborator, Robin MONZAT 👨⚕️ As Quality Director, Robin will strengthen Holodiag’s quality assurance and lead us towards GMP certification. #GMP #QA #BPF #recruitment
CPhI Barcelona 2023
This year again, we were delighted to be at CPhI ! This time in the beautiful city of Barcelona.
