! Big new toy for the lab !
A second X-Ray Powder Diffratometer from Malvern Panalytical has joined Holodiag’s lab ! Meet the twins right bellow !
Chemspec Basel 2023
Chemspec Europe is a key event for the fine and speciality chemicals industry. Like the last years, Holodiag is attending the event as a visitor. See you there on the 24th and 25th of May 2023 !
Cocrystals for pharma development
Cocrystal is an interesting crystalline structure for pharma development (bioavailabity, solubility). Dedicated investigations must be performed for identification : the so-called screening. Then further studies are necessary for an accurate description of the specific features (non-congruent solubility).
Polymorphism is a essential information !
According to ICH Q6A, polymorphism is described as: « The occurence of different crystalline forms of the same drug substance. This may include solvation or hydration products (also know as pseudopolymorphs) and amorphous forms. » Polymorphism is essential in pharma development for lead selection, solid form selection, regulatory affairs, IP, crystallization process development, robustness, and more.
OEL : 50 ng/m3
Holodiag’s analytical methods are apllicable to toxic samples down to 50 ng/m3. Thanks to laminar flow hood systems, HPAPIs, cytotoxic compounds and CMR substances can be handled with high security by our scientific team. Example of equipments under protection: • our Malvern Mastersizer 3000 for particle size distribution (Laser PSD) • our Dynamic Vapor Sorption […]
TGA and DSC are key thermal analyses for solid state characterization
Indeed, these analyses allow to get information about: • melting • (re)crystallization • stable/metastable phases • monotropy/nantiotropy • amorphous/Tg • hydrates/solvates • decomposition/degradation • temperature • enthalpy • stability • compatibility and more ! Holodiag owns a Mettler DSC 3+ and TGA-DSC 3+.
Challenging lyophilisate !
Drug products produced by lyophilization are typically amorphous and show higher dissolution rate and sulubility. However, undesired crystallization may occur, resulting in a lower dissolution rate or even undesirable particles. Holodiag performs specific investigations to identify crystalline particles, their origin in order to solve these situations.
BioFit Strasbourg 2022
Holodiag will attend as a visitor the new edition of BioFit based in Strasbourg this year ! See you there in three weeks !
CPhI Frankfurt 2022
Are you facing issues or are you looking for scientific discussions related to solid state characterization, polymorphism, crystallization processes ? Holodiag attends CPhI in Frankfurt as a visitor, can’t wait to meet you there !
About InfraRed
InfraRed is a well-known technique for molecular structure identification. It is also used to identify polymorphism in solid samples. Holodiag performs these analyses on high potent product down to 50 ng/m3.
