ELECTRON DIFFRACTION

Diffraction expertise:
X-Ray & Electrons

Holodiag expertise in diffraction (20 years in XRPD) now includes the electron diffractometer, opening new possibilities in crystallographic analysis.

Electron diffraction

Electron diffraction is the most recent addition to the crystallographic toolkit and allows researchers to determine crystal structures directly from nanocrystals.

The ELDICO ED-1 – is designed by crystallographers for crystallographers with many different applications.

Compared to traditional SCXRD, the single crystal required is much smaller (from dozen of µm to dozen of nm), and a raw data acquisition much faster (from hours/days to minutes).

ED-1 advantages

  • A game-changer for organic materials
  • Fast and direct access to crystal and molecular structures
  • No need for large single crystals : powder sample straight “from the flask”
  • Collect data to secure patents based on structure determination
  • Save time, resources and material

X-Ray powder diffraction

Holodiag’s X-ray Powder Diffraction Capabilities

A robust, routine technique integrated into daily operations
• Two in-house systems, including one dedicated to future GMP workflows
• Capacity: hundreds of analyses per week
• Fully integrated across all Holodiag service offerings
• High-potent samples OEL : 50 ng/m³

At Holodiag, we use X-ray powder diffraction to generate unique “fingerprints” of crystalline structures.

It is the daily powerful tool for identifying and characterizing solid forms, supported by ED to produce solid and reliable reference data (crystal structures).

XRPD advantages

  • Daily routine “work-horse” technique
  • High analysis capacity
  • Wide range of samples: powders, suspensions, tablets, ointments..
  • Toxic samples
  • From 10mg sample size

Expertise

At Holodiag, we have the skills, the equipment, the knowledge, in other words: a full expertise on diffraction.

We can perform analyses and also understand and solve the related solid state issues: polymorphism, hydrate, hygroscopicity, particle size, supersaturation, IP and more.

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