Differential Scanning Calorimetry (DSC)

Holodiag owns a high precision Differential Scanning Calorimeter (DSC). Our DSC, a DSC3+ (Mettler) allows to work on a broad range of temperatures (- 70°C up to more than 300 °C). Heating and cooling rates (from 0.01 °C/min up to 100 °C/min) allow to find the best compromise between resolution and intensity of the thermal events, depending on the aim of the analysis.

Differential Scanning Analysis allows the characterization of thermal events as a function of temperature. It is used in numerous applications:

  • Polymorphic transitions
  • Melting / degradation
  • Thermal stability (e.g. additive effects)
  • Security testing
  • Amorphous content
  • Glass transition
  • Characterization of desolvation
  • Quantification, etc.

The variety of available sample pans allows to design a large diversity of analyses. Samples can be prepared in a glove box under inert gas to avoid any degradation or transformation before analysis. The integrated sample changer gives high throughput capabilities.

Thermo-Gravimetric Analysis (TGA)

Holodiag also owns a high precision Thermo-Gravimetric Analysis (TGA). Our thermal analyzer, a Pyris 1 TGA (Perkin Elmer) enables working on a broad range of sub-ambient temperatures (up to 1000 °C). Heating rates (0.1 to 50 °C/min) give flexibility and better adjustment to experimental needs. Moreover, the high sensitivity of the micro-balance (0.1 µg) and its precision enable sharp detection of the most subtle phenomena. Results can easily be correlated to complementary calorimetric or structural analyses.

Thermo-gravimetric analysis allows to follow weight losses of a sample as a function of temperature. It is used in numerous applications:

  • Desolvation / dehydration
  • Stability control (solvates/hydrates)
  • Degradation
  • Loss on ignition
  • Quantification, etc.

Dynamic Vapor Sorption (DVS)

Holodiag owns a Dynamic Vapor Sorption (DVS) device. Our system, a DVS Intrinsic (SMS), allows to monitor sample mass variation vs. Relative Humidity (RH). This enables accurate depiction of hydrate stoichiometry and stability, hygroscopicity and drying conditions.

Our DVS system is enclosed in a safety hood and we can thus safely analyze all kinds of toxic samples (0.05 µg/m3).