Crystallization screening of polymorphic forms or solvates gives the opportunity to identify a maximum number of solid phases, in order to protect the development against late stage development problems (e.g. appearing of a new phase) or to secure your intellectual property.

Screening studies give access to a huge amount of information concerning the physicochemical characteristics of your molecule (phases with a high solubility, most stable form, filtrability, compressibility, pharmacokinetics, ...).

Background of the study

We investigate on known data and, when necessary, we can perform a preliminary study in order to optimize the parameters to be studied during the screening process (e.g. characteristics of the starting materials, measurement of solubilities, ...). We can then direct the choices towards the most appropriate crystallization processes and build DOE accordingly.

Packages

We offer 3 different packages to fulfill your needs:

• Focused
• Extended
• Custom-built

Characterization

Each sample is analyzed by powder X-ray diffraction, which allows to maximize the data collected within the time lapse. Most promising candidates can be further analyzed. Analytical and experimental data retrieved during the screening process enable you to choose the "final candidates".

What you get

And now ?

If the results from the screening process do not allow to narrow down the list of candidates or if you need additional data, we perform post-screening studies on stability (thermodynamic/statistic), solubility, ... You can then choose the most appropriate phase(s) according to the characteristics needed. When your best candidates have been selected, we can scale-up the process from few dozen of milligram up to the kilo lab.

Information and cost

Should you need more details or a quotation, please contact us.