Crystallization process development

Holodiag offers crystallization process development of small organic molecules

Holodiag offers crystallization process development of small organic molecules

Holodiag offers crystallization process development of small organic molecules. Our main fields of operations include:

  • Product recovery
  • Yield / Purity optimization
  • Crystallinity improvement
  • Particle engineering
  • Control of solid state
  • Isomer separation (e.g. cis/trans, Z/E, enantiomers)
  • Filtration and drying
  • Critical parameters and robustness

Crystallized samples are easier to handle, chemically purified and generally exhibit improved stability. Our scientific team performs the development of crystallization conditions according to the molecule’s polymorphism, solubility, supersaturation, nucleation and growth.

Filtration and drying are studied as full parts of the crystallization process. We also work on troubleshooting, robustness and optimization of existing processes.

Strong knowledge in thermodynamics of heterogeneous equilibria and phase diagrams allows us to identify critical parameters and optimize the process with good robustness.

Holodiag also has deep expertise in enantiomer separation by crystallization.

Our crystallization processes are optimized from lab-scale up to the kilo-lab. We can produce non-GMP batches. When the reproducibility of a process is challenged during scale-up, our experts can step in to make a diagnostic and propose necessary amendments.

We offer our customers real-time monitoring of studies through scheduled reporting and steering committees. All delivered reports provide detailed information and advice to make the right choices for all further development steps.